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Solway, Julian
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overview Walter L. Palmer Distinguished Service Professor of Medicine and Pediatrics Dean for Translational Medicine Director, Institute for Translational Medicine I am Dean for Translational Medicine and founding Director of the Institute for Translational Medicine, home of the University of Chicago-Rush University NIH/NCATS CTSA award. I have served the CTSA Consortium as a co-Chair, Steering Committee member, and co-Chair of the Strategic Goal 3 and Collaboration/Engagement Domain Task Force. My research programs primarily address asthma. I have extensive experience studying airway smooth muscle (ASM) function and dysfunction in asthma, having studied smooth muscle specific gene transcription, protein accumulation, and hypertrophy, and signaling mechanisms that regulate these; ASM contraction and its reversal, and the mechanisms that regulate these; and ASM mediated-airway narrowing, airway constrictor responsiveness, and lung function in both animal models and humans. Additional studies address asthma genetics and therapeutics in mechanistic and therapeutic clinical studies and preclinical development of novel asthma treatments. Recently, I have focused on the inhibition of pulmonary fibrosis and on the inhibition of breast cancer metastasis using novel small molecules discovered in our asthma studies. I directed the University of Chicago's NHLBI-sponsored T32 Research Training Program in Respiratory Biology for 25 years, led or co-led two NHLBI Multidisciplinary K12 Training Programs, co-led an NIH Broadening Experiences in Scientific Training (BEST) award, and currently lead a Burroughs Wellcome Fund Physician Scientist Institutional Award. My ORCID is 0000-0002-0898-8530. My Scopus ID is 7006796752. My NIH COMMONS name is jsolway. BS 1974 Massachusetts Institute of Technology (Electrical Engineering) MD cum laude 1978 Harvard University (Medicine) Residency 1981 Brigham and Women's Hospital (Internal Medicine) Fellowship 1983 Harvard Medical School (Pulmonary Medicine)
One or more keywords matched the following items that are connected to Solway, Julian
Item TypeName
Concept Evaluation Studies as Topic
Concept Drug Evaluation, Preclinical
Concept Mice, Inbred Strains
Concept Mice, Transgenic
Concept Models, Genetic
Concept Models, Theoretical
Concept Mice, Inbred BALB C
Concept Mice, Inbred C57BL
Concept Cohort Studies
Concept Linear Models
Concept Case-Control Studies
Concept National Institutes of Health (U.S.)
Concept Mice, Knockout
Concept Cross-Over Studies
Concept Mice
Concept National Heart, Lung, and Blood Institute (U.S.)
Concept Disease Models, Animal
Concept Follow-Up Studies
Concept Longitudinal Studies
Concept Mice, Mutant Strains
Concept Models, Biological
Concept Prospective Studies
Concept Retrospective Studies
Academic Article Developmental pattern of expression and genomic organization of the calponin-h1 gene. A contractile smooth muscle cell marker.
Academic Article 2A3 and 3F9. Novel lung epithelial antigens with early upregulation in hyperoxic and radiation lung injury models.
Academic Article p172: An alveolar type II and Clara cell specific protein with late developmental expression and upregulation by hyperoxic lung injury.
Academic Article Construction and uses of a concentric catheter for gas sampling in lung airways.
Academic Article Hyperoxia-induced airway remodeling in immature rats. Correlation with airway responsiveness.
Academic Article Sequence and structural analysis of feline interleukin-5 cDNA.
Academic Article Expression and cytogenetic localization of the human SM22 gene (TAGLN).
Academic Article Gas dispersion in volume-cycled tube flow. II. Tracer bolus experiments.
Academic Article Ipratropium bromide increases the ability of the nose to warm and humidify air.
Academic Article Hyperoxia-induced airway hyperresponsiveness and remodeling in immature rats.
Academic Article Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families.
Academic Article The nasal passage of subjects with asthma has a decreased ability to warm and humidify inspired air.
Academic Article Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma.
Academic Article Natural and induced allergic responses increase the ability of the nose to warm and humidify air.
Academic Article Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammation.
Academic Article A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma.
Academic Article Treatment of nasal inflammation decreases the ability of subjects with asthma to condition inspired air.
Academic Article The use and misuse of Penh in animal models of lung disease.
Academic Article Methodologic advancements in the study of airway smooth muscle.
Academic Article Functional characterization of evolutionarily conserved DNA regions in forkhead box f1 gene locus.
Academic Article Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice.
Academic Article Expression cloning identifies transgelin (SM22) as a novel repressor of 92-kDa type IV collagenase (MMP-9) expression.
Academic Article Inhibition of Th2-mediated allergic airway inflammatory disease by CD137 costimulation.
Academic Article Elevation of the nasal mucosal surface temperature after warming of the feet occurs via a neural reflex.
Academic Article Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation.
Academic Article Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness.
Academic Article Effects of surface tension and viscosity on airway reopening.
Academic Article Myosin, transgelin, and myosin light chain kinase: expression and function in asthma.
Academic Article p70 Ribosomal S6 kinase is required for airway smooth muscle cell size enlargement but not increased contractile protein expression.
Academic Article Lysophosphatidic acid enhances pulmonary epithelial barrier integrity and protects endotoxin-induced epithelial barrier disruption and lung injury.
Academic Article Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma.
Academic Article Differential induction of CD38 expression by TNF-{alpha} in asthmatic airway smooth muscle cells.
Academic Article Genomic medicine and lung diseases.
Academic Article Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice.
Academic Article Dilatation of the constricted human airway by tidal expansion of lung parenchyma.
Academic Article Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells.
Academic Article Finite difference analysis of respiratory heat transfer.
Academic Article Properties of steady maximal expiratory flow within excised canine central airways.
Academic Article Interdependent regional lung emptying during forced expiration: a transistor model.
Academic Article Influences of parenchymal tethering on the reopening of closed pulmonary airways.
Academic Article Pressure, flow, and density relationships in airway models during constant-flow ventilation.
Academic Article Expiratory flow limitation and dynamic pulmonary hyperinflation during high-frequency ventilation.
Academic Article Upstream stimulatory factor 1 activates GATA5 expression through an E-box motif.
Academic Article Airway reopening pressure in isolated rat lungs.
Academic Article Recovery of airway structure and function after hyperoxic exposure in immature rats.
Academic Article Structure and expression of a smooth muscle cell-specific gene, SM22 alpha.
Academic Article Alternative promoter and GATA5 transcripts in mouse.
Academic Article Gas mixing during high-frequency ventilation: an improved model.
Academic Article Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Academic Article Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.
Academic Article Nuclear import of serum response factor in airway smooth muscle.
Academic Article Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS).
Academic Article Mechanical and structural plasticity.
Academic Article Airway smooth muscle in the pathophysiology and treatment of asthma.
Academic Article Stiffness-activated GEF-H1 expression exacerbates LPS-induced lung inflammation.
Academic Article Gata5 deficiency causes airway constrictor hyperresponsiveness in mice.
Academic Article E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation.
Academic Article Airway contractility in the precision-cut lung slice after cryopreservation.
Academic Article Genome-wide interrogation of longitudinal FEV1 in children with asthma.
Academic Article Cyclooxygenase-2 and microRNA-155 expression are elevated in asthmatic airway smooth muscle cells.
Academic Article High-throughput screening for modulators of cellular contractile force.
Academic Article Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis.
Academic Article Future Research Directions in Asthma. An NHLBI Working Group Report.
Academic Article An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.
Academic Article DNA methylation in lung cells is associated with asthma endotypes and genetic risk.
Grant Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma Genes
Academic Article Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling.
Grant Preclinical development of myosolvins, a new class of medicine for asthma
Grant Dissecting the Genetic Architecture of Airway Hyperresponsiveness
Grant Illinois Precision Medicine Consortium (IPMC)
Academic Article Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.
Academic Article Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.
Academic Article Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results.
Academic Article Association of Vitamin D Levels, Race/Ethnicity, and Clinical Characteristics With COVID-19 Test Results.
Academic Article Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma.
Search Criteria
  • Preclinical
  • studies
  • using
  • mouse
  • models